Verrucous epidermal nevi: some aspects of pathogenesis and clinical cases
نویسندگان
چکیده
Verrucous epidermal nevi ― hamartomas of keratinocyte or appendages, located on the skin mucous membranes in form isolated birthmarks, less often have a linear localization. The pathogenesis verrucous has not been fully defined, probably development disease is associated with genetic mutations during embryogenesis and represent special mosaicism. are pathologies that require attention as potentially dangerous terms malignant neoplasms due to possible difficulties their diagnosis differential diagnosis.
 Analysis current data various forms nevi, presentation clinical cases nevi.
 article considers two nevus. Studies WEN shown presence changes expressed proteins by affected cells, such OGN, NT5C3A, ADD1, OLFML1, DHRS1, CALML5, SAMHD1, SFRP2, SPRR1B SERPINB13. This may indicate participation p53 signaling pathway, cellular response cytokine stimulus, disturbances cell adhesion differentiation Th1 Th2 cells. presented describe nevus order study disease, based picture. need for sometimes histological similarity other formations. Immunohistochemical examination, analysis using sequencing exome, proteomic cells help carry out mechanisms this will only diseases, but also allow finding new approaches its conservative therapy.
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ژورنال
عنوان ژورنال: Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei
سال: 2023
ISSN: ['2412-9097', '1560-9588']
DOI: https://doi.org/10.17816/dv112571